The human brain and the biological foundations of thought, feeling, and behavior

Biology is not the whole explanation

Thought, emotion, and behavior have biological foundations. What we pay attention to on a crowded street, what we remember from a conversation, and how we respond to stress are all connected to the ongoing activity of the nervous system, which works in concert with the rest of the body. In neuroscience, however, it is easy to fall into the trap of oversimplification. This happens when we assume that every human experience can be fully explained by identifying a particular brain region, a single neurotransmitter, or a pattern of neural activity.

Biology offers one level of explanation for human functioning. It allows us to describe the mechanisms underlying mental processes, but it does not always answer questions about their meaning. Describing the physiological processes through which the body responds to a stimulus is one thing; understanding why a particular situation matters so much to a particular person is another.

The brain does not operate independently of the body or the environment. It is part of a system in which incoming sensory signals, past experiences, fatigue, hunger, and our goals all influence how information is processed. Research on communication within brain networks and the organization of emotional processes suggests that the nervous system cannot be fully understood by assigning individual functions to individual brain regions.1–3

The brain as a system of interacting processes

Individual brain structures differ in their anatomy and degree of specialization, but their functioning also depends on their connections with one another. A single region may participate in many different tasks, while a complex mental process may involve several interacting structures. For this reason, neuroscience examines not only activity in specific regions but also the organization of neural networks and the ways brain regions exchange information.1

Does this mean that identifying the brain regions involved in particular functions no longer matters? Not at all. Specific structures and circuits play important roles in particular processes. The problem arises when we treat activity in a particular region as a complete explanation of how a psychological process works. Activity in a given region can provide an important clue, but its significance depends on the task and on how that region interacts with other structures.

This is evident in research on emotion and social cognition.2, 3 Rather than assuming that complex phenomena such as fear or empathy can be attributed exclusively to a single brain region, researchers examine the contributions of multiple structures and the patterns of interaction among them. These patterns may vary depending on the process and the situation.

Perception and attention: from signals to interpretation

Our senses do not work like a video camera that directly records the external world. The signals reaching the nervous system are often incomplete, variable, and susceptible to different kinds of interference. To recognize a familiar face, orient ourselves in space, and respond appropriately, the brain must select and integrate incoming information.

One approach to explaining this process is predictive processing, discussed, among others, by Andy Clark.4 According to this framework, the brain does not passively wait for stimuli but interprets sensory signals in relation to predictions based on previous experience. Mismatches between predictions and incoming information can influence subsequent processing. Predictive processing is an important framework in cognitive science, although it does not explain every aspect of perception.

Attention also plays an important role. We do not process all available stimuli with equal intensity. Which information is selected for further processing depends, among other things, on the properties of the stimulus and our current goals. Research on selective visual attention examines the neural mechanisms that help adjust information processing to the task at hand.5

What we notice, then, depends on both our surroundings and the mechanisms that select information. This does not mean that perception is entirely arbitrary or that every interpretation is equally accurate. It does, however, show that our access to reality depends on active information processing rather than merely on the passive reception of signals.

Memory and experience change the nervous system

Memory allows us to use information from the past in new situations. Its biological foundations include changes in synaptic function and molecular processes involved in the consolidation of memory traces.6 Memory, however, is neither a single mechanism nor a storage system filled with ready-made files. Different types of memory involve different processes, and encoding, consolidation, and subsequent retrieval are not the same thing.

A broader aspect of the nervous system's capacity to adapt is neuroplasticity: its ability to change in response to experience. This encompasses a range of phenomena, from changes at the cellular and synaptic levels to changes in the organization of larger networks. A review of research on physical activity, learning, and environmental enrichment suggests that these experiences may be associated with changes in the nervous system. The extent of these changes depends, however, on the population studied, the type of activity, and the methods used to measure them. 7

Here, it is worth maintaining a measured scientific perspective. Not every biological change in the brain automatically translates into improved cognitive abilities, and a better test score is not, in itself, evidence of lasting structural changes in neural tissue. These are related but distinct levels of analysis. To assess the significance of an observed change, we need to consider both how long the effect persists and whether it generalizes to other tasks.

Neuroplasticity reminds us that the biological foundations of the mind are not fixed. The nervous system can change in response to experience, but not all changes occur with equal ease, last equally long, or produce the same outcomes. What matters is not simply whether learning takes place, but also what we learn, under what conditions, and how we subsequently use that knowledge.

Emotion, the body, and the interpretation of situations

Emotions are associated with brain activity, physiological changes, and the appraisal of situations. Attempts to reduce them to a single brain structure or physiological response overlook the complexity of these processes. Research on emotion points to the involvement of large-scale neural networks that also participate in cognitive and social processes. 2, 3

Interoception the processing of information about the body's internal state is an important part of this picture. Signals related to heart rate, breathing patterns, and other physiological changes may contribute to emotional experience. 8 A bodily signal alone, however, does not always tell us what we are feeling. An elevated heart rate may accompany both fear in a dark alley and excitement before an important exam. The meaning of physiological arousal also depends on the context and on how we interpret the situation.

Reducing emotions to the interpretation of bodily signals would, however, be an overcorrection in the opposite direction. Emotions involve multiple interacting processes influenced by the external situation, previous experiences, and the body's current state. Similar physiological responses may accompany different experiences, and the same situation need not produce the same responses in different people.

The same caution applies when discussing neurochemistry. In popular culture, neurotransmitters are often presented as simple “mood elixirs.” Dopamine, however, is a neuromodulator whose effects depend, among other things, on how it is released, where its receptors are located, and how signaling unfolds across space and time. 9 It is therefore misleading to describe dopamine simply as the substance responsible for pleasure.

Serotonin should not be treated as the chemical equivalent of happiness, either. The serotonergic system includes many types of receptors and signaling mechanisms, and their effects depend on their location and interactions within neural circuits. 10 This does not mean that serotonin is irrelevant to mood. Rather, its role in mental processes cannot be reduced to a single emotion or a single, straightforward mechanism.

What does brain activity actually show?

One important methodological challenge in neuroscience is determining what conclusions about mental processes can be drawn from studies of brain activity. Neuroimaging techniques such as functional magnetic resonance imaging (fMRI) allow researchers to investigate relationships between signals associated with brain activity and the tasks people perform. Observing activity in a particular brain region does not, by itself, reveal which mental process a person is experiencing.

In neuroscience, this problem is known as reverse inference. 11 It involves inferring a cognitive process from activity in a brain region known to participate in that process. If activity in region X is observed in situations involving fear, it does not automatically follow that every instance of activity in that region indicates fear. Reverse inference is not inherently erroneous, but its reliability depends, among other things, on how distinctive that activity is of the process being studied. 12

If a particular region participates in many different tasks, simply observing its activity does not allow us to determine exactly what happened at that moment. A well-designed study, a precise hypothesis, and consideration of alternative explanations can, however, help us assess which conclusions are supported by the data.

When reading research on the brain, it is therefore worth distinguishing among three questions:

  1. Correlation: Does this brain activity co-occur with a particular behavior or task?
  2. Causation: Does this activity contribute to the behavior in question?
  3. Mechanism: What processes could account for the observed relationship?<

An answer to the first question does not automatically resolve the other two. Biological data help us test hypotheses and narrow the range of possible explanations, but they are not always sufficient on their own to explain what a particular behavior means to a particular person in their environment.

Explaining human functioning at more than one level

It is difficult to practice contemporary psychology rigorously without taking biology into account. At the same time, biological explanations do not invalidate other levels of analysis. Neural activity, the organization of brain networks, cognitive processes, a person's life history, and their social context need not be competing explanations, of which only one can be correct. They describe different aspects of human functioning.

A biological explanation may reveal the mechanisms that make a given process possible. A psychological explanation helps describe how that process unfolds in a particular task or experience. Environmental and social analysis helps us understand why similar mechanisms may be associated with different behaviors under different conditions.

Scientific thinking about human beings, then, is not simply a matter of assigning every phenomenon to the brain as quickly as possible. It also involves determining what biological data actually explain, where their explanatory power ends, and when we need to consider the broader context in which people live and act.

References

  1. Seguin, C., Sporns, O., & Zalesky, A. (2023). Brain network communication: Concepts, models and applications. Nature Reviews Neuroscience, 24(9), 557–574. DOI: 10.1038/s41583-023-00718-5
  2. Pessoa, L. (2017). A network model of the emotional brain. Trends in Cognitive Sciences, 21(5), 357–371. DOI: 10.1016/j.tics.2017.03.002
  3. Barrett, L. F., & Satpute, A. B. (2013). Large-scale brain networks in affective and social neuroscience: Towards an integrative functional architecture of the brain. Current Opinion in Neurobiology, 23(3), 361–372. DOI: 10.1016/j.conb.2012.12.012
  4. Clark, A. (2013). Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behavioral and Brain Sciences, 36(3), 181–204. DOI: 10.1017/S0140525X12000477
  5. Moore, T., & Zirnsak, M. (2017). Neural mechanisms of selective visual attention. Annual Review of Psychology, 68, 47–72. DOI: 10.1146/annurev-psych-122414-033400
  6. Kandel, E. R. (2001). The molecular biology of memory storage: A dialogue between genes and synapses. Science, 294(5544), 1030–1038. DOI: 10.1126/science.1067020
  7. Milbocker, K. A., Smith, I. F., & Klintsova, A. Y. (2024). Maintaining a dynamic brain: A review of empirical findings describing the roles of exercise, learning, and environmental enrichment in neuroplasticity from 2017–2023. Brain Plasticity, 9(1–2), 75–95. DOI: 10.3233/BPL-230151
  8. Greenwood, B. M., & Garfinkel, S. N. (2025). Interoceptive mechanisms and emotional processing. Annual Review of Psychology, 76, 59–86. DOI: 10.1146/annurev-psych-020924-125202
  9. Liu, C., Goel, P., & Kaeser, P. S. (2021). Spatial and temporal scales of dopamine transmission. Nature Reviews Neuroscience, 22(6), 345–358. DOI: 10.1038/s41583-021-00455-7
  10. Sharp, T., & Barnes, N. M. (2020). Central 5-HT receptors and their function; present and future. Neuropharmacology, 177, 108155. DOI: 10.1016/j.neuropharm.2020.108155
  11. Poldrack, R. A. (2006). Can cognitive processes be inferred from neuroimaging data? Trends in Cognitive Sciences, 10(2), 59–63. DOI: 10.1016/j.tics.2005.12.004
  12. Hutzler, F. (2014). Reverse inference is not a fallacy per se: Cognitive processes can be inferred from functional imaging data. NeuroImage, 84, 1061–1069. DOI: 10.1016/j.neuroimage.2012.12.075